The final proposed system of RBC vasodilation while in the presence of nitrite could be the reduction of nitrite to NO by Hb. Brooks initial analyzed the nitrite Hb conversation in 1937 which operate was afterwards prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to type metHb and NO (Brooks, 1937; … Read More